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Helenalin inhibits RELA. 5 / 7
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"Studies on the molecular mechanism by which this compound exert its anti-inflammatory effects have revealed that helenalin inhibits the transcription factor NF-κB, a central mediator of the human immu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16112419
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"In cortical neuronal cultures, we detected that the blockage of NF-κBp65 by helenalin abolished the glutamate-induced increase of the apoptotic index ( Fig. 8 )."
23727063
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"As Fig. 5 shows, at physiological pH 7.4, helenalin inhibited the binding of RelA to the DNA NF-κB binding sites with an IC 50 of 5.0 ± 2.8 μM, a value that compares favorably with the K D of the hele[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20175984
eidos
"[ 18-29 ] For example , helenalin is known to inhibit NF-kappaB p65 , [ 22 , 27 , 29 ] C / EBPbeta isoform selectively , [ 18 , 19 ] and c-Myb ."
33502811
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"For example, helenalin is known to inhibit NF-κB p65, C/EBPβ isoform selectively, and c-Myb."
33502811