IndraLab

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USP32 leads to the deubiquitination of NFE2L2. 3 / 3
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"Thus, we further assessed whether USP32 could inhibit the ubiquitination of NRF2 caused by Keap1 and whether LBT could promote the ubiquitination of NRF2 by targeting USP32."
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"Therefore, we tried to demonstrate whether USP32 inhibits the ubiquitination of NRF2 caused by Keap1 and whether LBT enhances the ubiquitination and degradation of NRF2 by targeting USP32 to induce ferroptosis."
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"The results demonstrated that USP32 markedly inhibited Keap1-mediated NRF2 ubiquitination, whereas LBT treatment effectively reversed the deubiquitination of NRF2 mediated by USP32 (Figure 4D)."
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