IndraLab

Statements

YOD1 activates NOD2. 2 / 2
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"Altogether, these findings show that YOD1 enhances NOD2 signaling in macrophages by stabilizing RIPK2."
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"In contrast to the non-catalytic regulation of TRAF6 by YOD1 (Schimmack et al, 2017), we found that the YOD1 C155A mutant failed to stabilize RIPK2, showing that the DUB activity is required for the effect of YOD1 on RIPK2.In summary, this study shows that YOD1 mediates optimal NOD2 signal transduction in macrophages and thereby ameliorates experimental colitis."
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