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Droperidol inhibits KCNH2. 6 / 11
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"In this system, current was activated at + 20 mV and deactivated at − 120 mV, the former resulting in small outward currents and the latter generating large and transient inward tail currents that are[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results are consistent with the hypothesis of a reduced cardiac repolarization reserve caused by the hERG blocker droperidol."
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"Molecular mechanisms of HERG current inhibition by droperidol were established using two-electrode voltage clamp recordings of Xenopus laevis oocytes expressing wild-type and mutant channels."
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"HERG tail currents following test pulses to 50 mV were inhibited by droperidol with an IC (50) of 77.3 +/- 9.6 nM (n = 8)."
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"Droperidol, in vitro, is a potent inhibitor of HERG [24,48]."
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"Finally, HERG K+ current elicited in HEK293 cells expressing high levels of HERG protein was decreased 50% by droperidol 32.2 nmol/L."
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