IndraLab

Statements

Droperidol inhibits KCNH2. 11 / 11
2 3 | 6
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"HERG tail currents following test pulses to 50 mV were inhibited by droperidol with an IC (50) of 77.3 +/- 9.6 nM (n = 8)."
18349188
ctd
No evidence text available
16757186
reach
"Molecular mechanisms of HERG current inhibition by droperidol were established using two-electrode voltage clamp recordings of Xenopus laevis oocytes expressing wild-type and mutant channels."
17457128
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"In conclusion, the higher sensitivity of anesthetized dogs towards sotalol induced QT prolongation is due to a reduced cardiac repolarization reserve caused by the hERG blocker droperidol."
16757186
ctd
No evidence text available
14678746
ctd
No evidence text available
28551711
reach
"Finally, HERG K+ current elicited in HEK293 cells expressing high levels of HERG protein was decreased 50% by droperidol 32.2 nmol/L."
10636190
tas
No evidence text available
21185626
reach
"The hERG K+ current was blocked by D,L-sotalol (IC50 approximately 1.2 mM, IC20 approximately 250 microM) and droperidol (IC50 approximately 0.1 microM, IC20 approximately 0.02 microM)."
16757186
tas
No evidence text available
15911273
reach
"The repolarization reserve of the latter was reduced by neurolept anesthesia using the hERG blocker droperidol (0.25 mg/kg/h yielding mean plasma concentrations of 0.5 microM)."
16757186