IndraLab

Statements

OTUD3 binds MYL12A. 5 / 5
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"Immunofluorescence showed OTUD3 and PD-L1 colocalization (Fig. xref ), and CO-IP experiments verified OTUD3’s interaction with MYL12A in Farage cells (Fig. xref )."
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"OTUD3 interacts with MYL12A and rupatadine."
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"However, rupatadine reduced MYL12A’s binding to wild-type OTUD3 (Fig. xref ), indicating that while the C76A mutation doesn’t affect binding, rupatadine can disrupt their interaction."
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"Further CO-IP experiments confirmed OTUD3 and MYL12A interaction in Farage cells, with immunofluorescence showing their colocalization (Fig. xref )."
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"Results showed the M2 region of OTUD3 (amino acids 53–196) primarily interacts with MYL12A’s M2 region (amino acids 18–171, Fig. xref )."
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