IndraLab

Statements

USP46 activates methane. 3 / 3
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"The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6."
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"These findings provide in vivo evidence that the Usp46 complex increases signaling strength by stabilizing Arrow/LRP6 and consequently promoting the cytoplasmic accumulation of Arm/β-catenin in Wingless-responding cells."
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"Finally, to test if the Usp46 complex promotes the deubiquitylation and resultant stabilization of the plasma membrane pool of endogenous Arrow, we performed cell surface biotinylation of S2R+ cells."
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