IndraLab

"For instance, association of several voltage-dependent calcium channel genes such as CACNA1C and CACNA1B was reported in large-scale GWAS for BD. xref , xref A pathway analysis of GWAS data suggests enrichment of calcium channel-related pathways among the genes empirically associated with BD. xref Studies of peripheral blood cells have consistently demonstrated altered intracellular calcium signaling in BD. xref , xref Lithium, the first-line therapeutic drug for BD, modulates inositol-mediated pathways xref and thereby regulate calcium ion release from the endoplasmic reticulum. xref When we performed a GO enrichment analysis using DAVID xref , xref by integrating the data of de novo protein-altering mutations in our study, common single-nucleotide polymorphisms associated with BD in a large-scale GWAS xref and rare CNVs implicated in BD xref (total no. of unique input genes=229, see xref for details), ‘calcium signaling pathway (hsa04020)' was the only term significantly enriched after performing correction for multiple testing ( P corrected =6.4 × 10 −3 , Bonferroni correction; note that significant enrichment of ‘calcium signaling pathway (hsa04020)' after correction was not observed when we submitted candidate genes from each study)."