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COPS6 increases the amount of CDC25A. 3 / 3
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"Fig. 5 C shows that PDGF significantly increased Cdc25A protein level ( P < 0.05), whereas loss of CSN6 by siRNA silencing decreased the protein level of Cdc25A from 1.74-fold to 0.91-fold over contro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, we speculate that CSN6 decreases β-TrCP and subsequently increases the expression of Cdc25A by competition with CSN5 and thereby inhibition of cullin deneddylation."
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"To further investigate whether elevation of CSN6 up-regulates the expression of Cdc25A by increasing β-TrCP ubiquitinated degradation in PDGF-stimulated PASMCs, cells were incubated with MG-132 (10 μM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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