IndraLab

Statements

SCN8A inhibits INS. 3 / 3
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"However, when tolbutamide, a specific blocker of the ATP sensitive K+ channel (KATP channel), was present, the magnitude of MED inhibition of insulin secretion was not influenced, suggesting that Kv-channel activity alteration, but not that of KATP channels, is involved in MED associated insulin secretory inhibition."
23171706
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"In subjects with metabolic syndrome, the combination of MeD with moderate-to-high intensity training induces greater improvement in health related quality of life with a greater effect on physical and functional fitness, body weight, enhanced EPCs, and decreased insulin sensitivity, triacylglycerols, and blood pressure than diet alone [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"These results indicate that DEX and MED inhibit insulin secretion through an alpha2-adrenoceptor and PTX sensitive GTP binding protein pathway that eventually involves Kv channel activation and Ca2+ channel inhibition."
23171706