IndraLab

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USP9X leads to the deubiquitination of REV1. 2 / 2
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"Protein stability, in vitro ubiquitination level assays, and protein half-life experiments confirmed that USP9X can downregulate the ubiquitination of REV1, which positively regulates REV1 protein expression."
38802791
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"USP9X mediates the deubiquitination of REV1, and aberrantly expressed REV1 acts as a scaffolding protein to assist Rad18 in interacting with CTH, promoting the ubiquitination and degradation of CTH and inducing remodeling of the Gly/Ser/Thr metabolism, which leads to radioresistance."
38802791