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Oxime inhibits UCHL1. 5 / 5
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"LDN-57444 (also referred to as compound 30) is an isatin o-acyl oxime that exhibits active site-directed inhibition of UCHL1 (IC 50 = 0.88 μM) preferentially relative to UCHL3 (IC 50 = 25 μM) [88] ."
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"It is, however, quite possible that loss of USP14 protein does not elicit the same effect on cells as inhibition of enzyme activity.LDN-57444 is an isatin O-acyl oxime reported to selectively inhibit [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"LDN-57444 is an isatin O -acyl oxime reported to selectively, competitively, and reversibly inhibit UCHL1 [119] ."
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"Isatin O-acyl oximes efficiently inhibit UCH-L1 and tumor growth in lung cancer cells."
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"By utilizing high-throughput screening (HTS) to find inhibitors and traditional medicinal chemistry to optimize their affinity and specificity, we have identified a class of isatin O-acyl oximes that selectively inhibit UCH-L1 as compared to its systemic isoform, UCH-L3."
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