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USP5 increases the amount of Interferon. 8 / 8
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"For example, a study by Yao et al. in zebrafish further demonstrated that USP5 activates higher levels of IFN by increasing RIG-I protein levels, thereby achieving antiviral functions [69]."
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"USP5 can increase interferon expression by increasing the expression level of retinoic acid-inducible gene protein I (RIG-I) through increasing the expression of vitamin A (retinoic acid) induced gene[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results show that overexpression of USP5 enhanced the mRNA levels of IFNφ1 ( Fig. 3 A) and Viperin ( Fig. 3 B), Mx1 ( Fig. 3 C), and ISG15 ( Fig. 3 D)."
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"These results indicated that USP5 enhanced the expression levels of IFNφ1 and ISGs.To study the function of USP5, USP5 or Vector with RIG-I were co-transfected in FHM cells."
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"Analysis of cellular RNA isolated from co-transfected FHM cells with USP5 or Vector and poly (I: C) showed USP5 activated higher IFN levels in the presence or absence of poly (I: C) ( Fig. 4 C)."
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"In zebrafish, USP5 activates higher levels of interferon by increasing the RIG-I protein level and thus restricts the virus replication [15] ."
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"RIG-I was tested as an activator Poly (I:C), which shows that USP5 was able to activate higher levels of IFNφ1 under Poly (I:C) stimulation."
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"For example, Jian Yao et al showed that USP5 activates higher levels of IFN by increasing RIG-I protein levels [69]."
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