IndraLab

Statements

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"USP37 up-regulation promoted the proliferation, cell cycle progression, apoptosis inhibition, migration, invasion, epithelial mesenchymal transition (EMT) and stemness of CRC cells; moreover, USP37 facilitated the angiogenesis of human umbilical vein endothelial cells (HUVECs)."
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"Similar to the observations in 2D, in the 3D culture platform too, the transient inhibition of USP37 decreased the proliferation rate of the encapsulated cells; however, the results were more faithfully mimicking the conditions in vivo."
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"XREF_BIBR Therefore, it is possible that IH mediated miR-320b reduction in lung cancer cells resulted in the upregulation of USP37, which further promoted cancer cell proliferation, invasion, and survival."
33898105
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"When tested on DLBCL cells, USP37 increased cell proliferation and inhibited cell cycle progression."
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"Accumulating evidence has demonstrated that USP37 promotes lung cancer cell proliferation, migration, and invasion XREF_BIBR but inhibits lung cancer cell apoptosis in a deubiquitination dependent manner."
33898105
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"For example, USP2, USP22, USP28, and USP37 stabilize c-Myc expression and, thus, stimulate the proliferation of many tumour cells [58–61] ."
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"These results demonstrated that USP37, serving as a potential DUB, de‐polyubiquitylated and stabilized ERα via removing the K48‐linked ubiquitination.3.5 USP37 promotes cell proliferation through ERalpha ."
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"USP37 promotes cell proliferation by stabilizing 14-3-3gamma."
26427597
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"On the other hand, USP37 shRNAs inhibited the proliferation of keloid fibroblasts with diminished c-Myc and Collagen I expression."
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"Notably, our results showed that overexpression of USP37, but not USP37 (C350S), enhanced the proliferation of cancer cells when 14-3-3gamma was co-transfected."
26427597
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"Depletion of USP37 also reduces cell proliferation and increases sensitivity to drugs inducing replication stress."
38516408
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"Knockdown of USP37 inhibits cell proliferation and induces apoptosis To investigate the latent role of USP37 gene in the transformation of breast cancer cells , cell proliferation was examined by CCK-8 assay ."
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"Depletion of USP37 also reduced cellular proliferation and led to increased sensitivity to agents that induce replication stress."
34509474
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"Functionally, overexpression of USP37 promotes cell proliferation and metabolism."
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"Interestingly, in non-neural cells (293T and HeLa cells), decreased USP37 was found to increase proliferation; however, this occurred due to the deubiquitination of cyclin A [29] ."
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"We found that lower expression level of USP37 obviously impaired the expression of Hh targets (Smo and Gli-1) and cell proliferation marker Ki-67 in the tumor tissues as seen by immunohistochemical staining (Fig. 8e)."
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