IndraLab

Statements

USP22 leads to the methylation of CTNNB1. 3 / 3
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"In addition, considering that the ubiquitination of β-catenin could be reduced by the inhibition of demethylase activity of KDM2A and the methylation of β-catenin increased by USP22, we speculate that there may be a competition between the methylation and ubiquitination modification of β-catenin."
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"Further, the upregulation of nuclear USP22 induced by HPC promotes the methylation of nuclear β-catenin after USP22-mediated deubiquitination, which enhances the stability of nuclear β-catenin in CA1 and protects ischemic neuron against cerebral ischemia."
39934243
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"Our data revealed that nuclear β-catenin deubiquitination induced by USP22 overexpression significantly increased the methylation of nuclear β-catenin after tGCI."
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