IndraLab

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Paeoniflorin inhibits RELA. 3 / 3
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"Previous studies have demonstrated that paeoniflorin antagonizes TNF-α-induced apoptosis by suppressing NF-κB p65 activation [45], ameliorates atherosclerosis by inhibiting TLR4-mediated NF-κB activation [46,47], and exerts anti-psoriatic effects via the p38 MAPK pathway [48]."
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"As shown in Fig. 6 A, LPS induced intra-nuclear translocation of p65, which was inhibited by the combination of paeoniflorin and luteolin."
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"Furthermore, paeoniflorin attenuated the activity of nuclear factor-κB p65 unit, tumor necrosis factor-α, interleukin (IL)-1β and IL-6, and reduced the COX-2 protein expression level."
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