IndraLab

Statements

reach
"SmUCHL5 was expressed at low levels at 10 µM, and research on mammalian cells has shown that the inhibition of UCHL5 and USP14 activates autophagy and apoptosis ( Feng et al., 2014 ; Kim et al., 2018 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33577811
reach
"A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance."
28604120
reach
"Recently, novel small molecule inhibitors of the deubiquitylating enzymes USP14 and UCHL5 were developed to overcome bortezomib resistance and induce cell apoptosis of multiple myeloma XREF_BIBR, XREF_BIBR."
33046988
reach
"UCH37 depletion also decreases both cell proliferation and apoptosis induction in functional assays."
26396186
reach
"Small molecule inhibitors of UCHL5 could induce apoptosis of multiple myeloma cells and reverse bortezomib resistance [XREF_BIBR]."
32351584
reach
"Inhibition of USP14 and UCHL5 activates caspase and triggers apoptosis of ER + BCa cells."
30250021
reach
"Along with others, we previously have been reported that inhibition of USP14 and UCHL5 of the 19S proteasome induces apoptosis."
28617443
reach
"Pharmacologic inhibition of USP14 and UCHL5 with VLX1570 induces apoptosis in drug resistant WM cells and is associated with accumulation of high-molecular-weight polyubiquitinated protein conjugates."
27813535
reach
"Finally, in vitro experiments confirmed that UCHL5 knockout enhances apoptosis in cervical cancer cells and disrupts Wnt/beta-catenin signaling."
39702250
reach
"For example, researchers have discovered inhibitors, like b-AP15 to covalent inhibition of both USP14 and UCHL5 to induce the cathepsin-dependent apoptosis by inhibiting the UPS system [131]."
37658402
reach
"UCHL5 knockdown enhances apoptosis and impairs Wnt/beta-catenin pathway in cervical cancer."
39702250
reach
"This reduction was associated with a significant increase in Cleaved Caspase-3 and the pro-apoptotic protein BAX, coupled with a corresponding decrease in the anti-apoptotic protein BCL-2, indicating that UCHL5 knockdown promotes apoptosis in these cells (Fig. 9F)."
39702250
reach
"Using MTT assay, Western blot, Hoechst 33342 staining assay and flow cytometry, we found that silencing of UCH37 in A549 cells induced apoptosis."
21287580
eidos
"Upregulation of UCHL5 promoted cell viability , attenuated apoptosis , and accelerated cell cycle in AN3-CA cells ."
32596150
reach
"A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance."
24319254
reach
"UCHL5 knockdown descended the relative viability of HCE-1-A cells measured by CCK-8 kits (Figure 3C) and augmented the percentage of apoptosis cells (Figure 3D)."
32596150
reach
"Moreover, UCHL5 overexpression decreased the percentage of apoptosis cells and sub-G1 population (Figures 4D,E)."
32596150
reach
"Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenstrom macroglobulinaemia tumour cells."
25691154