IndraLab

Statements

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"Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenstrom macroglobulinaemia tumour cells."
25691154
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"Moreover, UCHL5 overexpression decreased the percentage of apoptosis cells and sub-G1 population (Figures 4D,E)."
32596150
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"UCH37 depletion also decreases both cell proliferation and apoptosis induction in functional assays."
26396186
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"UCHL5 knockdown descended the relative viability of HCE-1-A cells measured by CCK-8 kits (Figure 3C) and augmented the percentage of apoptosis cells (Figure 3D)."
32596150
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"A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance."
24319254
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"Furthermore, cyclin-dependent kinase 4/6 (CDK4/6) inhibition decreased UCHL5 expression, suppressed OTX015-R cell proliferation, and induced apoptosis."
34954522
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"Inhibition of USP14 and UCHL5 activates caspase and triggers apoptosis of ER + BCa cells."
30250021
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"Along with others, we previously have been reported that inhibition of USP14 and UCHL5 of the 19S proteasome induces apoptosis."
28617443
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"Recently, novel small molecule inhibitors of the deubiquitylating enzymes USP14 and UCHL5 were developed to overcome bortezomib resistance and induce cell apoptosis of multiple myeloma XREF_BIBR, XREF_BIBR."
33046988
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"Small molecule inhibitors of UCHL5 could induce apoptosis of multiple myeloma cells and reverse bortezomib resistance [XREF_BIBR]."
32351584
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"Using MTT assay, Western blot, Hoechst 33342 staining assay and flow cytometry, we found that silencing of UCH37 in A549 cells induced apoptosis."
21287580
eidos
"Upregulation of UCHL5 promoted cell viability , attenuated apoptosis , and accelerated cell cycle in AN3-CA cells ."
32596150
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"Pharmacologic inhibition of USP14 and UCHL5 with VLX1570 induces apoptosis in drug resistant WM cells and is associated with accumulation of high-molecular-weight polyubiquitinated protein conjugates."
27813535