IndraLab

Statements

Ponatinib inhibits JAK1. 2 / 3
1 | 2
reach
"Previous studies reported that ponatinib can reduce inflammation of obesity and influenza (Chen et al., 2019; Lin et al., 2022) due to its inhibitory effect on the two isoforms of JAK (JAK1 and JAK2)."
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"Ponatinib alone suppressed pStat3 (Y705) as efficiently as the combination of PD173074 and ruxolitinib in the presence of erlotinib or AZD6244, suggesting that ponatinib potently inhibits FGFRs and JA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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