IndraLab

Statements

USP21 activates CDKN2A. 2 / 2
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"For the first time, we show that targeting USP16 in a mouse model of AD rescues two aberrant aging pathways, Cdkn2a and BMP, which can restore self-renewal of NPCs, decrease astrogliosis, and retard cognitive decline (Figure 1)."
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"Triplication of Usp16 may also deubiquitinate H2Aub at gene promotors and activate the Cdkn2a gene, a critical regulator for cell senescence [18,33,34] (Figure 4C)."
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