IndraLab

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BRCC3 activates pyroptosis. 11 / 11
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"Therefore, these findings indicate that depletion of BRCC36 promotes ferroptosis and inhibits pyroptosis primarily by regulating HMGCR expression.2.6 BRCC36 Functions as an Oncogene in Hepatic Carcinoma."
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"Furthermore, BRCC36 promoted cell proliferation, migration, and invasion, while inhibiting ferroptosis and inducing pyroptosis in liver cancer cells."
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"Knockdown of BRCC3 represses NLRP3 inflammasome activation-dependent pyroptosis and cell damage in HUVECs."
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"BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome."
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"BRCC3 knockdown reduced the inflammation and pyroptosis caused by cerebral I/R injury and ameliorated neurological deficits in mice after MCAO."
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"The results demonstrated that NEAT1, BRCC3 expression and NLRP3 inflammasome activation-dependent pyroptosis were significantly increased in H/R-injured HUVECs, whereas silencing BRCC3 or NEAT1 attenuated H/R-induced injury and pyroptosis."
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"These results suggest that BRCC36 directly deubiquitinates HMGCR.2.5 BRCC36 Inhibits Ferroptosis and Promotes Pyroptosis."
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"Besides, BRCC3 could activate NLRP3 inflammasome-dependent pyroptosis (26), which could then promote tumor progression.In conclusion, UCA1 acted as an oncogene in pancreatic cancer by partly regulating miR-582-5p/BRCC3, which promoted cell proliferation, migration, and inhibited apoptosis."
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"50 BRCC36 overexpression upregulates GSDMD expression and induces chronic pyroptosis, both of which deteriorate the tumor microenvironment (TME) over time and accelerate tumor growth, but this needs to be further studied.Furthermore, THL could inhibit the activity of the BRCC36 enzyme, reduce HMGCR protein levels, and suppress tumor growth."
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"Conversely, the overexpression of BRCC3 in airway epithelial cells worsened DM-induced cell injury and inflammation while also enhancing the NLRP3 inflammasome and pyroptosis."
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"Since HMGCR is a key suppressor of ferroptosis and a substrate of BRCC36, we hypothesized that HMGCR is involved in BRCC36‐mediated ferroptosis and pyroptosis."
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