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TBX3 increases the amount of HCN4. 2 / 2
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"HCN4 expression is specifically stimulated in SAN tissue by Tbx3, a transcriptional repressor whose activation is... " That both Tbx3 and the gene expression it controls are of vital importance to normal heart function during development does not indicate a primary role of HCN4 (I f) in rate control."
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"However, TBX3 overexpression alone cannot completely reprogram mature cardiomyocytes into pacemaker cells, and induced overexpression of TBX3 was not sufficient to increase HCN4 expression in adult mouse atria (Bakker et al. 2008)."
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