IndraLab

Statements

TBX3 increases the amount of HCN4. 6 / 6
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"Similarly, Tbx3 is known to activate the gene expression of HCN4 and of the cardiac pacemaker-specific calcium channel Cav3.1 [55]."
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"However, TBX3 overexpression alone cannot completely reprogram mature cardiomyocytes into pacemaker cells, and induced overexpression of TBX3 was not sufficient to increase HCN4 expression in adult mouse atria (Bakker et al. 2008)."
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"The increase in HCN1 and HCN3 expression in our study can be explained by Ragunathan’s study [15], which revealed that when HCN4 is highly expressed by TBX3, HCN1 and HCN3 will be highly expressed as well [32]."
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"Tbx3 could activate the expression of Hcn4 and other pacemaker cell‐specific genes."
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"HCN4 expression is specifically stimulated in SAN tissue by Tbx3, a transcriptional repressor whose activation is... " That both Tbx3 and the gene expression it controls are of vital importance to normal heart function during development does not indicate a primary role of HCN4 (I f) in rate control."
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"As shown in figure 5, sustained β-adrenergic receptor blockade resulted in the loss of the day–night rhythm in transcripts for (i) the sinus node-specific Shox2 [35], (ii) Tbx3 and Tbx18, which regulate the pacemaking phenotype and can promote ectopic Hcn4 expression [36,37], and (iii) Mef2c, which is a direct regulator of Hcn4 [38]."
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