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USP48 increases the amount of HMGA2. 6 / 6
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"Our findings indicate that USP48 expression enhances HMGA2 protein expression in a dose-dependent manner (Fig. 2A)."
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"This study has identified that USP48 directly interacts with HMGA2, and overexpression of USP48 significantly increases the protein expression of HMGA2 while decreasing its ubiquitination."
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"USP48 promoted the migration and invasion of CRC cells by upregulating HMGA2 expression."
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"The enforced expression of USP48 significantly increased HMGA2 protein levels by inhibiting its degradation, while the deprivation of USP48 promoted HMGA2 degradation, thereby suppressing tumor invasion and metastasis."
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"Our findings demonstrate that only the expression of USP48-WT led to an increase in HMGA2 levels, while USP48-C98S had no effect on protein abundance (Fig. 2C and D)."
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"Moreover, the co-expression of USP48 shRNA counteracted the elevated endogenous HMGA2 levels induced by USP48 overexpression in both HEK293T and DLD1 cells (Fig. 2E and Fig. S2C)."
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