IndraLab

Statements

USP13 inhibits Cyclin. 2 / 2
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reach
"Our results showed that USP13 knockdown decreased the half-life of cyclin D1 and facilitated the degradation of cyclin D1 in GC cells (Fig. 4E, F), whereas enforced expression of WT USP13, but not the USP13-C345A mutant, prolonged the half-life of cyclin D1 and delayed its degradation (Fig. 4G, H)."
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reach
"To further explore whether proteasome degradation pathway is involved in USP13-mediated stability of cyclin D1, we treated the transfected cells with proteasome inhibitor MG132 and found that MG132 alleviated USP13 siRNA-induced cyclin D1 downregulation (Fig. 4I)."
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