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Chloroquine inhibits MYD88. 4 / 4
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"This model is consistent with our observation that the endosomal pH modulators, bafilomycin and chloroquine, attenuated the MyD88-independent (TRIF-dependent) signaling pathway ( Fig. 7 b)."
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"Chloroquine (CQ) has been shown to affect LPS-TLR4 colocalization and inhibit both MyD88 dependent and TRAM and TRIF dependent pathways, though the mechanism involved is still poorly understood."
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"Chloroquine, a weak base that can partition into endosomes and perturb the pH, attenuated both MyD88-independent and MyD88-dependent pathways ( Fig. 7 b and c); however, bafilomycin, a V-type ATPase p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Chloroquine, an inhibitor of CpG triggered cytokine secretion, blocked TLR9 and MyD88 dependent cytokine secretion as expected but failed to inhibit CpG induced Src family kinase activation and its dependent cellular responses."
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