IndraLab

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"] Our previous work revealed that USP22 was able to promote HCC stemness by a HIF1alpha / USP22 positive feedback loop and mediate multidrug resistance ( MDR ) by activating the SIRT1 / AKT / MRP1 pathway ."
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"Our previous research showed that ubiquitin specific peptidase 22 ( USP22 ) induces multidrug resistance of HCC via the Sirtuin 1 ( SIRT1 ) / AKT / multidrug resistance associated protein 1 ( MRP1 ) signaling pathway151 ; and recently we also explored the relationship among USP22 , sorafenib resistance , and cancer stemness.152 Precision therapy is the future direction of cancer treatment ."
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