IndraLab

Statements

Ubiquitinated TP53 binds ATXN3. 2 / 2
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reach
"We have observed that the Josephin domain of ATX-3 is sufficient for the direct binding of ATX-3 to native p53, whereas the ubiquitinated p53 interacts with ATX-3 primarily through the UIMs, indicating that UIMs function to help recruit and bind the ubiquitinated p53 (XREF_FIG)."
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reach
"Ataxin-3 (ATXN3), a member of the MJD DUB family, also directly binds to native and polyubiquitinated TP53 and deubiquitinates and stabilizes TP53 by repressing its degradation through the ubiquitin–proteasome pathway [44]."
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