IndraLab

Statements

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"Physiologically, USP11 depletion suppresses cell proliferation and wound healing in lung epithelial cells, and these effects are reversed by E2F1 and PEG10 overexpression."
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"Functionally, USP11 mediated stabilization of p21 inhibits cell proliferation and tumorigenesis in vivo."
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"USP11 has an important impact on the development and progression of multiple cancers, and previous studies have shown that targeting USP11 can significantly inhibit the proliferation and migration of multiple cancers."
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"Knockdown of USP11 promotes cell proliferation, migration, and invasion in a YAP-dependent manner [36]."
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"USP11 depletion decreases DLBCL cell proliferation."
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"Ablation of USP11 or RAE1 reduces cell proliferation of U2OS cells."
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"Altogether, these results indicate that USP11 is a KLF4‐specific deubiquitinase that promotes KLF4 degradation.3.3 USP11 mediates cancer cell proliferation and tumorigenesis by promoting KLF4 instability."
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"Tanggang Deng et al. [32] identified that USP11 inhibits the proliferation of non-small cell lung cancer via deubiquitinating and stabilizing P21 (Fig. 4)."
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"Notably, other than a finding that loss of one allele of Usp11 in male mice destabilizes PTEN to promote mouse embryonic fibroblast (MEF) and prostate epithelial cell proliferation and tumorigenesis (31), all the findings on the role of USP11 in tumorigenesis and cell differentiation were achieved from cell culture-based systems."
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"In contrast, HOXC5 overexpression reversed the effect of proliferation and apoptosis induced by USP11 silencing."
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"Functionally, USP11 mediated melanoma cell proliferation via the regulation of NONO levels because ablation of USP11 inhibits the proliferation which could be rescued by ectopic expression of NONO protein."
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"Our observation that depletion of USP11 or inhibition using a non specific inhibitor such as Mitoxantrone significantly reduces DLBCL proliferation further supports the need for the development of USP11 specific inhibitors for targeting DLBCL."
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"Interestingly, USP11 may also inhibit breast cancer cell proliferation through deubiquitinating PTEN (31); however, no genetic evidence indicates that USP11 suppresses mammary tumorigenesis."
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"Weitong Zhang et al. [38] found USP11 promotes the proliferation and migration of colorectal cancer, and the Circ-DOCK1/MiR-132-3p axis further repressed USP11 transcription."
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"Tanggang Deng et al. [32] found that USP11 inhibits the proliferation of colorectal cancer via deubiquitinating and stabilizing P21, which depends on the intact function of P21."
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