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CYLD inhibits CASP8. 2 / 2

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"As shown in XREF_FIG, upon selenite treatment, cIAPs were degraded, and CYLD transcription was upregulated, causing degradation of RIP1 K63 ubiquitin chains and subsequent DISC formation, caspase-8 activation and apoptosis."

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"Consistent with the data above, silencing CYLD largely abolished caspase 8 activation and necroptotic cell death induced by 5z-7 plus TNFalpha (XREF_FIG)."

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IndraLab

Statements

CYLD inhibits CASP8. 2 / 2

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