IndraLab

Statements

APP inhibits UCHL1. 3 / 3
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"It is also known that Abeta downregulates the UCHL1 in AD, thereby, compromising synaptic plasticity, as well as neuronal survival."
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"It has been found that Abeta may down-regulate Uch-L1 in the AD brain, which in turn impairs BDNF and TrkB mediated retrograde signaling, compromising synaptic plasticity and neuronal survival."
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"Further, our results support the idea that in AD, Abeta may down-regulate UCH-L1 in the AD brain, which in turn impairs BDNF and TrkB mediated retrograde signaling, compromising synaptic plasticity and neuronal survival."
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