IndraLab

Statements

Bepridil inhibits KCNH2. 10 / 18
3 4 1 | 10
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"The IC 50 for hERG block by bepridil was 2.65-fold, 5.94-fold and 6.77-fold higher when non-binding polystyrene, hydrophilic and polystyrene compound plates were used versus glass compound plates."
19442753
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"We considered longer term exposure as a possibility since we showed previously that bepridil inhibited hERG trafficking whereas verapamil and vanoxerine did not and we have confirmed these results in this study."
26616666
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"Of the MICE drugs only bepridil inhibited hERG trafficking following overnight exposure."
26616666
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"Consistent with a previous publication ( Stork et al., 2007 ), cisapride suppressed hERG current in a frequency-dependent manner (0.03 Hz: 89 ± 4% suppression at 15th AP pulse; 1 Hz: 70 ± 2% suppressi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28830713
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"Bepridil on the other hand blocks both hERG and Cav1.2 currents."
26616666
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"The effects of hERG blockers such as propafenone [23] and bepridil [10] were also reported to be selectively mediated by Phe656."
22020101
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"When expressed in transfected COS cells, HERG is blocked in a concentration dependent manner by bepridil (EC50 = 0.55 microM), verapamil (EC50 = 0.83 microM), and mibefradil (EC50 = 1.43 microM), whereas nitrendipine and diltiazem have negligible effects."
9765513
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"The explanation of a mitigated hERG channel blocking effect by Ca 2+ antagonism may not be considered entirely satisfactory, since bepridil, another Ca 2+ antagonist, also potently blocks the hERG cha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16289936
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"HERG is blocked by bepridil (EC50 = 0.55 microM), verapamil (EC50 = 0.83 microM) and mibefradil (EC50 = 1.43 microM), whereas nitrendipine and diltiazem have negligible effects."
10860024
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"This effect can be inhibited by the hERG blocker bepridil in a dose-dependent manner."
23369369