IndraLab

Statements

Bepridil inhibits KCNH2. 18 / 18
3 4 1 | 10
tas
No evidence text available
21185626
tas
No evidence text available
15911273
tas
No evidence text available
15324906
reach
"The IC 50 for hERG block by bepridil was 2.65-fold, 5.94-fold and 6.77-fold higher when non-binding polystyrene, hydrophilic and polystyrene compound plates were used versus glass compound plates."
19442753
drugbank
No evidence text available
15272206
reach
"We considered longer term exposure as a possibility since we showed previously that bepridil inhibited hERG trafficking whereas verapamil and vanoxerine did not and we have confirmed these results in this study."
26616666
reach
"Of the MICE drugs only bepridil inhibited hERG trafficking following overnight exposure."
26616666
ctd
No evidence text available
24052561
reach
"Consistent with a previous publication ( Stork et al., 2007 ), cisapride suppressed hERG current in a frequency-dependent manner (0.03 Hz: 89 ± 4% suppression at 15th AP pulse; 1 Hz: 70 ± 2% suppressi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28830713
ctd
No evidence text available
15671647
reach
"Bepridil on the other hand blocks both hERG and Cav1.2 currents."
26616666
ctd
No evidence text available
15272206
ctd
No evidence text available
14975710
reach
"The effects of hERG blockers such as propafenone [23] and bepridil [10] were also reported to be selectively mediated by Phe656."
22020101
reach
"When expressed in transfected COS cells, HERG is blocked in a concentration dependent manner by bepridil (EC50 = 0.55 microM), verapamil (EC50 = 0.83 microM), and mibefradil (EC50 = 1.43 microM), whereas nitrendipine and diltiazem have negligible effects."
9765513
reach
"The explanation of a mitigated hERG channel blocking effect by Ca 2+ antagonism may not be considered entirely satisfactory, since bepridil, another Ca 2+ antagonist, also potently blocks the hERG cha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16289936
reach
"HERG is blocked by bepridil (EC50 = 0.55 microM), verapamil (EC50 = 0.83 microM) and mibefradil (EC50 = 1.43 microM), whereas nitrendipine and diltiazem have negligible effects."
10860024
reach
"This effect can be inhibited by the hERG blocker bepridil in a dose-dependent manner."
23369369