IndraLab

Statements

Bepridil inhibits KCNH2. 12 / 12
3 4 | 5
tas
No evidence text available
15911273
tas
No evidence text available
15324906
ctd
No evidence text available
14975710
tas
No evidence text available
21185626
ctd
No evidence text available
15671647
ctd
No evidence text available
24052561
reach
"Bepridil on the other hand blocks both hERG and Cav1.2 currents."
26616666
reach
"When expressed in transfected COS cells, HERG is blocked in a concentration dependent manner by bepridil (EC50 = 0.55 microM), verapamil (EC50 = 0.83 microM), and mibefradil (EC50 = 1.43 microM), whereas nitrendipine and diltiazem have negligible effects."
9765513
reach
"We considered longer term exposure as a possibility since we showed previously that bepridil inhibited hERG trafficking whereas verapamil and vanoxerine did not and we have confirmed these results in this study."
26616666
ctd
No evidence text available
15272206
reach
"HERG is blocked by bepridil (EC50 = 0.55 microM), verapamil (EC50 = 0.83 microM) and mibefradil (EC50 = 1.43 microM), whereas nitrendipine and diltiazem have negligible effects."
10860024
reach
"Of the MICE drugs only bepridil inhibited hERG trafficking following overnight exposure."
26616666