IndraLab

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Isoflurane inhibits NLRP3. 6 / 6
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"Anesthetic isoflurane inhibits the NLRP3 inflammasome in the MRL and lpr SLE mouse model [XREF_BIBR]."
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"Isoflurane Enhances Autophagy by Activating AMPK / ULK1 , Inhibits NLRP3 , and Reduces Cognitive Impairment After Cerebral Ischemia-Reperfusion Injury in Rats ."
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"Isoflurane has been demonstrated to inhibit the activation of the NLRP3 inflammasome and show neuroprotective effects."
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"Anesthetic isoflurane (ISO) abrogated the formation and activation of NLRP3 inflammasome and markedly mitigated renal injuries in SLE-prone mice [ 52 ]."
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"In addition, Li et al. demonstrated that A20, a TNF induced protein 3 (TNFAIP3) known as a negative modulator of inflammation, markedly suppressed the activation of NLRP3 inflammasome and mitigated LN symptoms in pristine induced lupus mice [XREF_BIBR], and Yuan et al. reported that isoflurane abrogated the formation and activation of renal NLRP3 inflammasome and ameliorated renal dysfunction and injury in MRL and lpr lupus mice [XREF_BIBR]."
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"Injection of Ac-YVAD-cmk (an NLRP3/caspase 1 inhibitor) prior to anesthesia did improve cognitive impairments and prevent hippocampal inflammation in aged mice, but not in young mice, which was possibly due to the attenuation of isoflurane-triggered NLRP3 inflammasome [9]."
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