IndraLab

Statements

USP8 deubiquitinates GRIA. 3 / 3
| 3
reach
"This homeostatic mechanism is directly antagonized by NMDAR-dependent activation of the deubiquitinating enzyme ubiquitin carboxyl-terminal hydrolase 8 (USP8), to favor AMPAR deubiquitination and therefore AMPAR recycling (Scudder et al., 2014)."
30568574
reach
"Furthermore, shRNA mediated knockdown of USP8 is sufficient to enhance the basal level of AMPAR ubiquitination in primary neurons."
29123470
reach
"In addition to USP46, USP8 can also deubiquitinate mammalian AMPARs indicating that multiple regulatory mechanisms exist to control AMPAR ubiquitination levels (Scudder et al., 2014)."
29302259