IndraLab

Statements

USP8 leads to the deubiquitination of GRIA. 3 / 3
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"Furthermore, shRNA mediated knockdown of USP8 is sufficient to enhance the basal level of AMPAR ubiquitination in primary neurons."
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"This homeostatic mechanism is directly antagonized by NMDAR-dependent activation of the deubiquitinating enzyme ubiquitin carboxyl-terminal hydrolase 8 (USP8), to favor AMPAR deubiquitination and therefore AMPAR recycling (Scudder et al., 2014)."
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"In cultured neurons, an elevated presence of USP8 decreases the level of agonist-induced AMPAR ubiquitination, resulting in heightened expression of surface GluA1 and synaptic AMPARs [179]."
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