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OTUB1 activates ferroptosis. 9 / 9
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"OTUB1 has been shown to directly interact with and stabilize the xCT transporter: knockdown of OTUB1 led to growth suppression of mice tumor xenografts and reduced activation of ferroptosis (Liu et al., 2019)."
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"Solasonine, an alkaloid constituent of Solanum nigrum L., has induced ferroptosis in PC cell lines through degradation of SLC7A11 by Otubain-1 (OTUB1)-mediated ubiquitination ( Liang et al., 2022 )."
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"Notably, the downregulated OTUB1 was found to promote podocyte injury in LN by regulating ferroptosis."
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"In this context, OTUB1 might be a potential target for new therapies of OSCC.As a key and star deubiquitinating enzyme, OTUB1 mediates ferroptosis, immunity, apoptosis, and autophagy in tumor and non-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Liu et al. discovered a distinct mechanism by which OTUB1 mediates ferroptosis in bladder cancer via the stabilization of SLC7A11 (123).3.2.3 MINDY1."
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"Additionally, our data suggest that skeletal muscle development induced by OTUB1 through the ferroptosis pathway may do duty for a potential target for treating skeletal muscle-related diseases.Interestingly, numerous studies have demonstrated a significant correlation between ferroptosis and autophagy ."
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"The OTUB1 can mediate ferroptosis via the stabilization of SLC7A11 in human cancer [39]."
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"In summary, our findings indicate a causative role of OTUB1 in ferroptosis inhibition, suggesting that the absence of OTUB1 activates autophagy-dependent ferroptosis in skeletal muscle that induces significant muscle loss and weakness."
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"Next, we explored the role of OTUB1-mediated ferroptosis in regulating skeletal muscle formation."
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