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"ACO has also been found capable of blocking the Kv1.5 channels that mediate the outward ultra-rapidly activating delayed rectifier K + current (I Kur ) in neonatal rat ventricular myocytes [ xref , xref ] while studies also demonstrated that ACO inhibited hERG in Xenopus laevis oocytes [ xref ] and HEK293 cells [ xref ]."