IndraLab

Statements

reach
"Prostaglandin E 2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cAMP in human macrophages."
25917098
reach
"It has also been shown that prostaglandin E2 can inhibit NLRP3 inflammasome activation by inducing PKA signaling."
29163487
reach
"MSC derived PGE 2 inhibited TGF-beta-activated kinase 1 (TAK1) signaling and NLRP3 inflammasome activation in liver macrophages to decrease the production of inflammatory cytokines."
33413632
reach
"Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages."
25917098
reach
"PGE2-dependent suppression of NLRP3 inflammasome in liver macrophages resulted in down-regulated secretion of inflammatory cytokines (IL-1β, IL-6 and IL-18) which led to the alleviation of acute liver inflammation[17]."
36161038
reach
"MSC derived PGE 2 inhibited TAK1 signaling and NLRP3 inflammasome activation in liver macrophages; meanwhile, MSC derived PGE 2 could also induce M2 macrophages to secret anti-inflammatory cytokines, like IL-10 to promote inflammation resolution and limit liver injury through activating STAT6 and mTOR signaling in macrophages, finally to inhibit the liver inflammatory response and hepatocyte apoptosis induced by LPS and D-Gal."
33413632
reach
"Similar findings were reported by Miao and colleagues who provided evidence that PGE2-dependent repression of NLRP3 inflammasome in Kupffer cells was mainly responsible for beneficial effects of BM-MSCs in the attenuation of acute liver injury during lipopolysaccharide (LPS)-induced sepsis in mice[18]."
36161038