IndraLab

Statements

OTUB1 increases the amount of OTUB1. 5 / 5
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"PKP3 upregulates OTUB1 expression by increasing OTUB1 mRNA stability."
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"The overexpression of OTUB1 significantly increased the mRNA level of OTUB1 but failed to elevate the mRNA level of OTUB1‐isoform2 (P < .01, Figure 2D)."
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"Consistently, the overexpression of OTUB1‐isoform2 significantly increased the mRNA level of OTUB1‐isoform2 but failed to elevate OTUB1 at either the mRNA (P < .01, Figure 2E) or the protein level (Figure 2F)."
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"FTO, as an m A demethylase, erases the m A modification of the OTUB1 transcript, which up-regulates the expression of OTUB1 and leads to radiotherapy resistance of NPC [17]."
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"We transfected T24 and EJ cells with gradient OTUB1 OE plasmid and OTUB1 siRNA respectively, OTUB1 expression levels were induced gradually by OTUB1 OE plasmid and restrained by designed siRNA (Fig. 3B, C)."
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