IndraLab

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Curcumin inhibits JUN. 28 / 29
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"Curcumin inhibits the activity of activator protein-1, a transcription factor implicated in the expression of Abeta [XREF_BIBR]."
32283762
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"This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK and c-Jun signaling pathway activity."
32083122
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"Curcumin also suppressed the JNK and c-Jun activation in those cells."
19763044
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"We previously reported that curcumin, the yellow pigment of turmeric, inhibited the formation of the Fos, Jun, and DNA complex."
12104052
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"The role of JNK (and thereby c-Jun) and NF-kappaB transcription factor in the induction of MMP-13 by TNF-alpha was explored by pretreating human chondrocytes or SW1353 chondrocytic cells with curcumin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12878172
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"Moreover, curcumin downregulates other crucial transcription factors responsible for controlling cell growth and survival pathways, including signal transducer and activator of transcription 3 (STAT3), cyclooxygenase 2 (COX2), Akt, antiapoptotic proteins and activator protein 1 (AP1) 69,92,93."
30540121
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"Curcumin derivatives inhibit the formation of Jun, Fos, and DNA complex independently of their conserved cysteine residues."
16053715
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"Results also revealed that curcumin treatment decreased LPS induced activation of two transcription factors -- nuclear factors kappaB (NF-kappaB) and activator protein-1 (AP-1)."
18368483
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"Curcumin inhibits NF-kappaB and activator protein 1, responsible for cytokine transcription, in cell lines."
25628521
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"Curcumin and emodin block the CSN directed c-Jun signaling pathway, which results in diminished c-Jun steady state levels in HeLa cells."
16083495
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"Up-regulation of COX-2 and the above ER signaling factors was reversed by treatment of the infected cells with curcumin which specifically inhibits the JNK and c-Jun pathway."
16036795
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"The role of JNK (and thereby c-Jun) and NF-kappaB transcription factor in the induction of MMP-13 by TNF-alpha was explored by pretreating human chondrocytes or SW1353 chondrocytic cells with curcumin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12878172
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"Another study found that curcumin inhibited VEGF and a wide range of downstream MAPK-related components including c-Jun-p, Ras, Grb2, MEKK3, and MKK7, however, levels of JNK and ERK seemed to be upregulated (S. S. Lin et al., 2009)."
34867402
eidos
"In addition , curcumin inhibits the activation of NF-kB and the expression of c-jun , c-fos , c-myc ."
16216010
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"Curcumin treatment in Ishikawa cells (endometrial carcinoma) induces apoptosis, cell-cycle arrest in phase S, and the downregulation of ERK and Jun mRNA, as well as the reduction of the p-ERK-2/c-Jun pathway."
34744708
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"Curcumin is known to mediate MMP1 and MMP3 activities by inhibiting the signaling pathways of PKCdelta and JNK and c-Jun."
32995615
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"Curcumin also inhibits 12-O- tetradecanoyl phorbol-13-acetate-mediated induction of c-jun / AP-1, ornithine decarboxylase, and protein kinase C activity in murine NIH/3T3 cells (Huang et al., 1992)."
11322385
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"We also tested whether inhibition of nuclear factor kappa-B (NF-kappaB) and activator protein-1 (AP-1) by curcumin is involved in these mechanisms."
16461119
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"This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity."
32083122
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"Curcumin is a potent inhibitor of the transcription factor activator protein-1 which plays an essential role in osteoclastogenesis."
19699734
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"We previously reported that curcumin, the yellow pigment of turmeric, inhibited the formation of the Fos, Jun, and DNA complex."
12104052
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"Curcumin is a potent inhibitor of the transcriptional factors activator protein-1 and nuclear factor-kappaB."
10799655
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"Curcumin has been proven to inhibit p-Jun N-terminal kinase p-JNK and c-jun [5] in neuropathic pain model and inhibit tumor necrosis factor TNF-α and nitrogen monoxide (NO) in a diabetic mouse model of neuropathic pain [4]."
25135388
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"New and known symmetrical curcumin derivatives inhibit the formation of Fos, Jun, and DNA complex."
12104052
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"XREF_FIG shows that curcumin selectively inhibits the transcriptional activity of c-Jun and c-Fos but not c-Jun and Fra -1 in the absence of exogenous Zac1 (XREF_FIG; closed bars)."
26633653
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"Another study reported that curcumin suppresses activation of C-Jun N-terminal kinases (JNK), which belongs to the mitogen active kinase family (MAP kinase) and is activated in response to inflammatory cytokines and stress conditions [2, 86]."
34671402
ctd
No evidence text available
17596214
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"Hyaluronic Acid Modified Curcumin-Loaded Chitosan Nanoparticles Inhibit Chondrocyte Apoptosis to Attenuate Osteoarthritis via Upregulation of Activator Protein 1 and RUNX Family Transcription Factor 2."
35180907