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Curcumin inhibits JUN. 46 / 49
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"Therefore, curcumin on induction or prevention of cell death may be associated with factors such as cell species, kinds of stress and/or doses of curcumin administered.In summary, curcumin induces NPM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin has been previously shown to inhibit the transcription factor AP-1 and modulate its dimer composition [13,26] ."
16380075
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"Fullbeck and co-workers demonstrated that curcumin blocks the CSN-directed c-Jun signaling pathway, which results in diminished c-Jun steady-state levels in HeLa cells [64]."
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"Curcumin inhibited the NF-κB, AKT and activator protein-1 (AP-1) activation."
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"This result is controversial, since curcumin is an inhibitor of c -Jun, JNK, ERK and NF-κB and ATRA activates JNK in some breast cancer cell lines, such as MCF7, while curcumin inhibits [ 5 ]."
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"Curcumin has also been reported to impede the expression of mRNA of c-FOS, c-JUN, c-MYC, and iNOS , the Wnt target genes in various cancer cells ( Teiten et al., 2012 )."
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"Another study found that curcumin inhibited VEGF and a wide range of downstream MAPK-related components including c-Jun-p, Ras, Grb2, MEKK3, and MKK7, however, levels of JNK and ERK seemed to be upregulated (S. S. Lin et al., 2009)."
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"The potential of curcumin to downregulate transactivation and expression makes it possible for it to suppress the function of several transcription factors, including the androgen receptor, activator protein-1 (AP-1), NF-kB, and cAMP."
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"it phosphorylates IκBα, c-Jun, as well as p53 and its activity is inhibited by curcumin [10,51,52] ."
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"Curcumin inhibits the activation of NF-κB and the expression of oncogenes including c- jun , c- fos , c- myc , NIK, MAPKs, ERK, ELK, PI3K, Akt, and CDKs."
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"Curcumin inhibits NF-kappaB and activator protein 1, responsible for cytokine transcription, in cell lines."
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"Up-regulation of COX-2 and the above ER signaling factors was reversed by treatment of the infected cells with curcumin which specifically inhibits the JNK and c-Jun pathway."
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"Pan et al. showed that curcumin-induced inhibition of c-Jun N-terminal kinases (JNKs) prevents dopaminergic neuronal loss by suppressing mitochondrial dysfunction in a PD mice model using the effects [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity."
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"Curcumin treatment has also been shown to promote apoptosis, the down-regulation of ERK and cell-cycle arrest in phase S and the inhibition of the p-ERK-2/c-Jun pathway in model cells of endometrial carcinoma [186]."
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"Moreover, curcumin inhibits PKC δ activity and its downstream signaling pathway, transcription factor AP-1 ( Balasubramanian and Eckert, 2007; Kunwar et al., 2007 )."
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"Curcumin inhibits the activation of C-Jun N terminal kinase by carcinogenesis, thus C-Jun phosphorylation is inhibited and consequently activation of AP-1 ( Zhang et al., 2019 )."
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"Curcumin has been proven to inhibit p-Jun N-terminal kinase p-JNK and c-jun [5] in neuropathic pain model and inhibit tumor necrosis factor TNF-α and nitrogen monoxide (NO) in a diabetic mouse model of neuropathic pain [4]."
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"Curcumin inhibits the activity of activator protein-1, a transcription factor implicated in the expression of Abeta [XREF_BIBR]."
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"First, curcumin inhibits the activation of nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-1) and cellular gene expression regulated by NF-kappaB, AP-1 and Egr-1 [14 -17]."
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"It was previously demonstrated that curcumin inhibited the binding of activator protein-1 (AP-1) to DNA [23] , and that CRT promoter contains putative binding sites for AP-1 [22] ."
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"Curcumin can also mediate the inhibition of c-Jun/AP-1 activation that results in a significant decrease in the activation of GAPDH mRNA and VEGF production by hypoxia [95,96] ."
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"Moreover, curcumin downregulates other crucial transcription factors responsible for controlling cell growth and survival pathways, including signal transducer and activator of transcription 3 (STAT3), cyclooxygenase 2 (COX2), Akt, antiapoptotic proteins and activator protein 1 (AP1) 69,92,93."
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"Additionally, c-Jun N-terminal kinases (JNK), histone methyltransferase p300, and transcriptional factor activating protein-1 (AP-1) were all inhibited by curcumin (Huwait et al., 2011)."
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"Results also revealed that curcumin treatment decreased LPS induced activation of two transcription factors -- nuclear factors kappaB (NF-kappaB) and activator protein-1 (AP-1)."
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"Chemopreventive mechanism revealed that curcumin blocks the binding of activator protein-1 (AP-1) in the promoter region of miR-21, thereby restoring the expression of tumor suppressor programmed cell[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_FIG shows that curcumin selectively inhibits the transcriptional activity of c-Jun and c-Fos but not c-Jun and Fra -1 in the absence of exogenous Zac1 (XREF_FIG; closed bars)."
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"The role of JNK (and thereby c-Jun) and NF-kappaB transcription factor in the induction of MMP-13 by TNF-alpha was explored by pretreating human chondrocytes or SW1353 chondrocytic cells with curcumin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Hyaluronic Acid Modified Curcumin-Loaded Chitosan Nanoparticles Inhibit Chondrocyte Apoptosis to Attenuate Osteoarthritis via Upregulation of Activator Protein 1 and RUNX Family Transcription Factor 2."
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"In addition, the transcriptional factor Activator Protein-1 (AP-1), which is known to be associated with anti-apoptotic, mitogenic, and pro-angiogenic genes, is downregulated by curcumin."
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"Curcumin treatment in Ishikawa cells (endometrial carcinoma) induces apoptosis, cell-cycle arrest in phase S, and the downregulation of ERK and Jun mRNA, as well as the reduction of the p-ERK-2/c-Jun pathway."
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"Curcumin also suppressed the JNK and c-Jun activation in those cells."
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"Furthermore, curcumin can downregulate intracellular transcription factors including activator protein 1 (AP-1), NF-kB, COX-2, matrix metalloproteinase-9 (MMP-9), and nitric oxide synthase (NOS)."
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"Curcumin is known to mediate MMP1 and MMP3 activities by inhibiting the signaling pathways of PKCdelta and JNK and c-Jun."
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"Curcumin and emodin block the CSN directed c-Jun signaling pathway, which results in diminished c-Jun steady state levels in HeLa cells."
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"The role of JNK (and thereby c-Jun) and NF-kappaB transcription factor in the induction of MMP-13 by TNF-alpha was explored by pretreating human chondrocytes or SW1353 chondrocytic cells with curcumin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Curcumin has been shown to regulate the production of pro-inflammatory cytokines tumor necrosis factor-α and inhibited the activation of transcription factors nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), which regulated the genes for pro-inflammatory mediators and protective antioxidant genes (13)."
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"Curcumin also inhibits 12-O- tetradecanoyl phorbol-13-acetate-mediated induction of c-jun / AP-1, ornithine decarboxylase, and protein kinase C activity in murine NIH/3T3 cells (Huang et al., 1992)."
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"Another study reported that curcumin suppresses activation of C-Jun N-terminal kinases (JNK), which belongs to the mitogen active kinase family (MAP kinase) and is activated in response to inflammatory cytokines and stress conditions [2, 86]."
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"Curcumin downregulates the activator protein-1, which is associated with anti-apoptotic, mitogenic, and pro-angiogenic genes."
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"Curcumin works by inhibiting the transcription factor AP-1, which is involved in the development of amyloid, a protein linked to AD."
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"Curcumin is a potent inhibitor of the transcription factors NF-κB (nuclear factor-κB) and activator protein-1 (AP-1), both of which have been implicated in the survival of osteoclasts [21–24] ."
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"By contrast, curcumin suppresses the activation of c-Jun/AP-1 in mouse fibroblast cells ( Huang et al., 1991 ) and inhibits the formation of Fos–Jun–DNA complex ( Hahm et al., 2002 )."
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"Therefore, the anticancer property of curcumin is most likely related to its ability to prevent NF-κB phosphorylation by IκB and downregulates activator protein-1 (AP-1) [ 131 ]."
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"Western blot analysis revealed that repeated intrathecal injections of curcumin significantly reduced the upregulation of c-Jun, p-c-Jun, CCL2, and CCR2 in the spinal cord (Figure 11(b) and (c))."
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"Curcumin derivatives inhibit the formation of Jun, Fos, and DNA complex independently of their conserved cysteine residues."
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