IndraLab

Statements



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"Then, we found that Fpr2 inhibition markedly reduced the activation of transforming growth factor beta activated kinase 1 (TAK1) induced by LPS."

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"We further found that LPS induced degradation of IRAK1 and phosphorylation of TAK1 were markedly inhibited in a berterion concentration dependent manner without changes in the levels of TLR4, MyD88, or TAK1 (XREF_FIG A)."

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"CPEB1 and CPEB4 knockdowns suppressed LPS activated TAK1 signaling cascades by reducing the levels of TNF-alpha and phosphorylated TAK1, p38, ERK, JNK, and NF-kappaB-p65 in THP-1cells."

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"As in the above studies, the LPS induced activation of TAK1 and IKK were both markedly reduced and delayed in Dream -/- cells compared with WT (XREF_SUPPLEMENTARY)."

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"4 '-HW suppressed LPS induced degradation of IkappaB-alpha and activation of IKK and TAK in RAW 264.7 macrophages."

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"USP18 alleviated LPS induced sepsis by inhibiting TAK1 activity."

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"USP18 alleviated LPS induced sepsis by inhibiting TAK1 activity."

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"LPS-induced activation of TAK1, an upstream regulator of NF-κB and MAPK pathways, was significantly inhibited by RRx-001 pretreatment, whereas recruitment of MyD88 to TLR4 was not affected by RRx-001."

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"The data indicate that DUSP11 inhibits LPS induced macrophage activation by targeting TAK1."