IndraLab

Statements

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"Cell apoptosis and cell cycle assays also showed that leupeptin abrogated the effect of USP18 on paclitaxol-induced cell apoptosis and cell cycle arrest in MDA-MB-231 cells ( Fig. 3 D&E)."
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"This suggests that increased USP18 caused by IAV infection promotes the induction of innate immune responses while promoting IAV replication.IAV can induce host cell apoptosis through an endogenous/mi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, all the above studies demonstrated that ISG15 and USP18 alone induced apoptosis in leukemia, myeloma and cervical cancer cells."
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"Consistent with these results, we observed enhanced GBP-1 expression and increased apoptosis in THP-1 and KT-1 cells treated with the USP18 aa 302-313 peptide (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Consistently, the loss of c-Myc reversed the cell cycle arrest and apoptosis induced by USP18 overexpression in SW1990 cells (XREF_FIG - XREF_FIG)."
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"However, the molecular mechanism responsible for apoptosis induced by USP18 in HCC and its relationship with ER stress remained unknown.The goal of this study was to determine if USP18 could regulate apoptosis and ER stress in HCC cells."
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"USP18 promoted HCC cell proliferation by inhibiting apoptosis."
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"Also, depletion of Usp18 led to a decrease in protein levels of other known oncogenic targets of miR-7, reduced cell proliferation and soft agar colony formation, and increased apoptosis."
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"These results suggest that USP18 can promote the continuous proliferation of HCC cells by affecting apoptosis."
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"More importantly, ISG15 and USP18 induced cancer cell apoptosis."
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"Inhibition of AKT attenuated the decrease in cell apoptosis induced by USP18 overexpression and increased cell viability and migration."
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"Deubiquitinase USP18 mediates cell migration, apoptosis and ferroptosis in lung adenocarcinoma by depending on POU4F1/PRKAA2 axis."
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"USP18 overexpression in vitro may protect PC12 cells from OGD/R-induced damage by modulating inflammatory responses and apoptosis."
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"XREF_BIBR - XREF_BIBR Consistent with this, an siRNA to the ISG, USP18, that deconjugates ISG15 from target proteins, increased expression of TRAIL and thus promoted apoptosis."
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"In summary, USP18 knockdown inhibited proliferation, migration but enhanced apoptosis and ferroptosis in LUAD cells."
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"Down-regulation of USP18 expression together with the induction of ER-stress efficiently restored apoptosis in U87MG cells."
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"Indeed, it has been shown that ablating USP18, the enzyme that deconjugates ISG15 from target proteins, increased TRAIL production and promoted the extrinsic apoptosis pathway in cells treated with IF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Identification of USP18 as an important regulator of the susceptibility to IFN-alpha and drug induced apoptosis."
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"27 Silencing USP18 in glioblastoma cells produces similar results, 84 a finding suggesting that strengthening the IFN-I pathway by silencing USP18 elicits apoptosis in drug treated cells with robust caspase-8 and caspase-3 activation independent of the mitochondrial pathway."
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"Collectively, these results indicated that USP18 knockdown inhibited the proliferation and induced the apoptosis of glioma cells."
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"These data demonstrate that USP18 promotes viral replication, induces innate immunity and apoptosis via cGAS-STING pathway in IAV-infected lung epithelial cells.USP18 is a negative regulator of IFN an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ectopic ISG15 and USP18 induce cancer cell apoptosis."
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"Downregulation of USP18 was initially reported to enhance apoptosis induced by IFN-α or TRAIL in different cell lines, activating the extrinsic apoptosis pathway and the associated upregulation of TRAIL (71)."
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