IndraLab

Statements

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"Indeed, it has been shown that ablating USP18, the enzyme that deconjugates ISG15 from target proteins, increased TRAIL production and promoted the extrinsic apoptosis pathway in cells treated with IF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Inhibition of AKT attenuated the decrease in cell apoptosis induced by USP18 overexpression and increased cell viability and migration."
35696596
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"Consistently, the loss of c-Myc reversed the cell cycle arrest and apoptosis induced by USP18 overexpression in SW1990 cells (XREF_FIG - XREF_FIG)."
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"Therefore, all the above studies demonstrated that ISG15 and USP18 alone induced apoptosis in leukemia, myeloma and cervical cancer cells."
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"XREF_BIBR - XREF_BIBR Consistent with this, an siRNA to the ISG, USP18, that deconjugates ISG15 from target proteins, increased expression of TRAIL and thus promoted apoptosis."
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"Identification of USP18 as an important regulator of the susceptibility to IFN-alpha and drug induced apoptosis."
20068173
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"Also, depletion of Usp18 led to a decrease in protein levels of other known oncogenic targets of miR-7, reduced cell proliferation and soft agar colony formation, and increased apoptosis."
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"Downregulation of USP18 inhibits growth and induces apoptosis in hepatitis B virus related hepatocellular carcinoma cells by suppressing BCL2L1."
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"27 Silencing USP18 in glioblastoma cells produces similar results, 84 a finding suggesting that strengthening the IFN-I pathway by silencing USP18 elicits apoptosis in drug treated cells with robust caspase-8 and caspase-3 activation independent of the mitochondrial pathway."
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"Down-regulation of USP18 expression together with the induction of ER-stress efficiently restored apoptosis in U87MG cells."
21858676
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"More importantly, ISG15 and USP18 induced cancer cell apoptosis."
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"Consistent with these results, we observed enhanced GBP-1 expression and increased apoptosis in THP-1 and KT-1 cells treated with the USP18 aa 302-313 peptide (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Ectopic ISG15 and USP18 induce cancer cell apoptosis."
27659523