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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CYLD inhibits necrotic cell death. 2 / 2

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"Interestingly, CYLD protein levels decreased in late-phase apoptosis, despite consistently upregulated mRNA levels (XREF_FIG), likely due to CYLD cleavage by caspase-8 to prevent necrosis."

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"22 Therefore, we propose that CYLD protein levels decrease to evade the necrosis elicited by sustained high CYLD levels."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...