IndraLab

Statements

reach
"Induction of cytokine expression resulting from innate immune signaling is also impacted by HCQ mediated reduction in DNA/RNA binding and activation of cGAS/STING signaling and altered endosomal pH also disrupts binding to TLR7/9."
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reach
"It is important to note that MyD88‐dependent signaling is not impacted by CQ, though it can be modulated by SARS‐CoV and is necessary for the protection in a murine challenge model.59 Furthermore, HCQ inhibits cyclic GMP‐AMP synthase (cGAS) activity in host cells.60 Activation of the cGAS/STING pathway by RNA/DNA‐dependent mechanism promotes increased type I interferon (IFNβ) production."
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