IndraLab

"CD designation Alternate names Expression pattern Function Significance Clinical use (B-cell malignancies only) CD5 CD10 CD11c CD19 CD20 CD22 CD23 CD79b Leu-1, Ly-1, T1, Tp67 CALLA α-subunit of αxβ2, p150,95 B4 B1, Leu-16, Bp35 HD39, BL-CAM, Lyb8 FcεRII, B6, Leu-20, BLAST-2 Igβ, B29 T cells, B1 subset of B cells Enterocytes, renal tubules, glomeruli, granulocytes, T cell and B cell precursors Monocytes, macrophages, NK cells, neutrophils, B cells and T cells All B cells A majority of B cells A majority of B cells, basophils B cells, platelets, macrophages, eosinophils, and follicular DCs1 Intracellular and variable surface expression on B cells Regulation of immune tolerance Zinc metallo-peptidase specific for cleavage of 1-3 N-terminal amino acids Cellular adhesion to fibrinogen Amplification of BcR2 signals in complex w/CD21 and CD80 Signal transduction – growth or death signals, Ca2+ channel Cell-cell adhesion, attenuation of BcR signals Low affinity IgE receptor Signaling component of the BcR Increased propensity for malignant transformation, production of auto antigens First antigen marker used in the diagnosis of malignant disease (ALL) Characteristically overexpressed on hairy cells T101 mAb against CLL (39,40) J5 mAb against ALL (41) none B cell specific surface CBL-CD19 mAb antigen against B-NHL (33,34) Target of 1st FDA IDEC-C2B8 mAb approved mAb, against B-NHL rituximab (IDEC-C2B8) (20,23,30,32) B cell specific surface Radiolabeled hLL2 antigen against B-NHL (42) Characteristically expressed on CLL cells none B cell specific surface none antigen Quantitative Flow Cytometry of B-Cell Neoplasms 97 Table 2: Antibody-fluorochrome panels used for clinical flow cytometry between the years 1997 and 2003."

"The children were eligible for minor surgery, and the adults were Early Decline in the Precursor B-cell Pool TABLE 1 The set of monoclonal antibodies used for the selected quadruple immunostainings to separate precursor B-cell subsets in normal bone marrow Combination CD Clone Fluorochromes Manufacturer 1 CD10 HI10A FITC BD Biosciences CD20 L27 PE BD Biosciences CD19 J4.119 PECy5 Immunotec CD45 2DI APC BD Biosciences 2 CD34 8G12 FITC BD Biosciences CD22 BL-CAM PE BD Biosciences CD19 J4.119 PECy5 Immunotec CD45 2DI APC BD Biosciences 33 Downloaded by [University of Wisconsin - Madison] at 11:32 13 January 2018 voluntary health care workers."

"A B-cell receptor CD22 is also known as B-lymphocyte cell adhesion molecule (BL-CAM), Sialic acid-binding Ig-like lectin 2 (Siglec-2) and T-cell surface antigen Leu-14."

"CD22 (UniprotKB—P20273) is also known as B-lymphocyte cell adhesion molecule (BL-CAM), sialic acid-binding Ig-like lectin 2 (Siglec-2), and T-cell surface antigen Leu-14."

"It was initially identified as a B-lymphocyte-specific transmembrane glycoprotein by Wilson et al. (1991), who cloned its full-length cDNA and designated it B-lymphocyte cell adhesion molecule (BL-CAM) [ xref ]."