IndraLab

Statements

OTUB1 increases the amount of CCN6. 3 / 3
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"Through overexpressing a panel of deubiquitinases, they identified that OTUB1 overexpression upregulates CCN6 protein levels."
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"To confirm this result, we transfected 4T1 cells with increasing amounts of plasmids encoding GFP‐tagged OTUB1 and found that OTUB1 increased CCN6 protein levels in cells in a dose‐dependent manner (Figure 1C)."
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"Consistently, overexpression of OTUB1 in OTUB1 4T1 cells inhibited CCN6 degradation (Figure 2B), showing that OTUB1 increases CCN6 protein levels by inhibiting its degradation."
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