IndraLab

Statements

COPS5 inhibits AP1. 6 / 6
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"NRBP exhibited a marked inhibitory effect on the c-Jun and Jab1-mediated AP-1 activation in a dose-dependent manner."
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"The cotransfection of HBx and Jab1 resulted in substantial activator protein 1 (AP-1) activation and knockdown of endogenous Jab1 attenuated AP-1 activation caused by HBx."
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"Consistently, we also observed a similar inhibitory effect of NRBP on the Jab1-induced AP-1 activation in Jurkat TAg cells in a dose-dependent manner (data not shown)."
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"As is shown in Fig. 9, group 1 that is transfected with AP-1-Luciferase and pCMV-Myc vector showed nearly no activity of the luciferase reporter, while overexpression of c-jun (group 2) and Jab1 (grou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We have demonstrated that CARP repressed JAB1 mediated AP-1 activation and enhanced p27 nuclei accumulation XREF_BIBR."
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"Moreover, overexpression of NRBP in mammalian cells significantly impaired Jab1-mediated AP-1 activation."
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