IndraLab

Statements

Pyrimidine inhibits JAK1. 2 / 2
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"XREF_BIBR, XREF_BIBR, XREF_BIBR AZD1480 is a novel pyrazol pyrimidine ATP-competitive inhibitor of JAK1 and 2 kinases, with IC50 's of 1.3 and < 0.4 n, respectively, in enzyme assays."
22829094
reach
"Additionally, the pyrazolyl pyrimidine AZD1480, which potently inhibits JAK1 (IC 50 value of 1.3 nM) and JAK2 (IC 50 value of 0.4 nM) 186, differentially suppressed STAT1, STAT3, STAT5 and STAT6 activation at 0.1-5 muM concentration in prostate, ovarian, glioma, and breast cancer cells in vitro XREF_BIBR, XREF_BIBR."
23903221