IndraLab

Statements

USP10 decreases the amount of TP53. 4 / 4
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"Interestingly, downregulation of USP10 significantly decreased p53 stabilization and the expression of p53 target genes p21 and Bax after DNA damage (XREF_FIG)."
20096447
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"On the other side, the ubiquitinated TP53 could be reversed and stabilized by USP7 and USP10, to keep the amount of TP53 in check."
31695837
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"Thus, depletion of USP10 would cause a decrease in p53 levels and lead to cisplatin resistance."
32382008
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"To confirm the role of USP10 in regulating p53 levels, we depleted USP10 using USP10 specific shRNA, and found that downregulation of USP10 decreased p53 protein levels with no effect on p53 mRNA levels (XREF_FIG)."
20096447