IndraLab

Statements

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"Most importantly, BIIB021 blocked the activity of K13, which was associated with a disruption of the K13-IKK complex."
23881928
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"NEMO is essential for the interaction of K13 with the IKK complex ( xref , xref )."
23881928
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"Essential Role of NEMO in Mediating K13-IKK Interaction and IKK Activation."
22590573
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"KSHV-encoded viral FLICE-inhibitory protein (vFLIP) K13 binds to the IkappaB kinase (IKK) complex to constitutively activate the NF-κB pathway, which has been shown to be essential for the survival and proliferation of PEL cells."
23881928
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"BIIB021 also blocked constitutive NF-κB activity present in PEL cells in part by blocking the interaction of vFLIP K13 with the IKK complex subunits."
23881928
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"To understand the mechanism by which HSP90 inhibitors block K13-induced NF-κB, we examined their effect on K13-IKK complex interaction in 293-pSLIK-TO-K13/NF-κB-Luc cells using a co-immunoprecipitation (co-IP) assay."
23881928
sparser
"Thus, HSP90 activity is required for the assembly of the K13-IKK complex and BIIB021 blocks K13-induced NF-κB activity by disrupting this complex."
23881928
sparser
"HSP90 inhibitors disrupt the interaction between K13 and the IKK complex."
23881928