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USP4 increases the amount of BRCA1. 2 / 2
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"Conversely, silencing USP4 expression increased endogenous BRCA1 ubiquitylation level in cells after MG132 treatment (Fig. 3c)."
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"Importantly, we further demonstrate that USP4 mutants (L301R, S315C and R559W) that are defective either in DUB activity or in interacting with BRCA1 can cause significant decrease in BRCA1 protein level and hence confer increased sensitivity to IR or anticancer drugs such as DOX, ETO or PARPi."
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