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Statements

CS binds OTUB2. 5 / 5
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"H&E and immunohistochemistry (IHC) staining indicated enhanced YAP/TAZ levels in the OTUB2-WT group, but not in the OTUB2-CS and OTUB2-KR groups ( Figure 5 H)."
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"Consistent with the idea that OTUB2 serves as a DUB for YAP/TAZ, we found that co-expression of OTUB2-WT, but not OTUB2-CS, decreased YAP/TAZ lysine 48 poly-ubiquitination detected in the presence of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pulse-chase labeling experiments showed that ectopic expression of OTUB2-WT, but not OTUB2-CS, prolonged the half-life of endogenous YAP ( Figure 3 L); Consistently, the turnover rate of TAZ as measur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB2-WT, OTUB2-CS, or OTUB2-K233R (KR) was ectopically expressed in 4T1 murine breast cancer cells, and the cells were injected under the nipple of BALB/c mice, which allowed us to examine both prima[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB2-WT expression increased spontaneous lung metastasis without affecting primary tumor growth, whereas expression of OTUB2-CS or OTUB2-KR had no significant effects ( Figure 5 E–5H)."
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