IndraLab

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USP22 deubiquitinates Histone-H2A. 9 / 9
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"Several DUBs have been implicated in histone deubiquitination, including USP3, USP12, USP22, and USP46, which deubiquitinate both histones H2A and histones H2B [XREF_BIBR]."
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"USP22 was initially reported to promote deubiquitylation of histones H2A and H2B, leading to transcription activation."
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"USP22 induces changes in gene promoter regions by deubiquitinating histones H2A and H2B, thereby controlling transcription."
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"Previous studies have demonstrated that USP22 deubiquitinates histones H2A and H2B and regulates cell growth, cell-cycle regulation and signal transduction (4,5,17)."
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"Apart from deubiquitinating histones H2A and H2B, USP22 also modulates transcription through stabilization of the p53-antagonizing deacetylase sirtuin-1 (SIRT1) to suppress p53-controlled transcription and to abrogate pre-mature senescence in pluripotent progenitor cells during embryonic development [5]."
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"In addition, USP22 can also enhance DNA damage repair by deubiquitinating histones H2A and H2Bub1."
35935969
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"USP22 is one subunit of SAGA (Spt-Ada-Gcn5-acetyltransferase), and is involved in the deubiquitination of histones H2A and H2B and the acetylation of histone H4 in order to regulate the transcription and expression of numerous genes (15,16)."
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"As we discussed previously, USP22 is a component of a transcriptional activator complex SAGA and can deubiquitinate histones H2A and H2B, as well as several other substrates (Zhang et al., 2008a, b)."
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"As a subunit of hSAGA, USP22 participates in the deubiquitination of histones H2A and H2B and the acetylation of histone H4 to regulate gene transcription and expression."
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