IndraLab

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USP22 deubiquitinates Histone-H2A. 4 / 4
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"As a subunit of hSAGA, USP22 participates in the deubiquitination of histones H2A and H2B and the acetylation of histone H4 to regulate gene transcription and expression."
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"USP22 was initially reported to promote deubiquitylation of histones H2A and H2B, leading to transcription activation."
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"Several DUBs have been implicated in histone deubiquitination, including USP3, USP12, USP22, and USP46, which deubiquitinate both histones H2A and histones H2B [XREF_BIBR]."
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"As we discussed previously, USP22 is a component of a transcriptional activator complex SAGA and can deubiquitinate histones H2A and H2B, as well as several other substrates (Zhang et al., 2008a, b)."
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