IndraLab

Statements

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"These results suggest that the PLC–IP 3 signaling pathway is important in mediating BK channel activation by DHA in vascular smooth muscle."
29636681
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"To test this hypothesis, we determined the mechanisms of BK channel activation by DHA at different concentrations using patch clamp techniques and cytosolic calcium fluorescent ratio measurements."
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"This endothelium independent relaxation suggested that DHA may have activated smooth muscle K 2P channels or other K + channels like the large-conductance Ca 2+ -activated channel KCa1.1 as also described previously [XREF_BIBR, XREF_BIBR]."
23724868
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"XREF_BIBR recently showed that the omega-3 fatty acid docosahexaenoic acid (DHA) activates the Slo1 large-conductance Ca 2+ - and voltage gated K + (BK) channel, which is present in vascular smooth muscle cells and plays a role in regulating vascular tone."
24277599
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"An essential fatty acid in humans, DHA is not normally found in the fruit fly Drosophila; here, XREF_BIBR compared its effects on human and Drosophila Slo1 (hSlo1 and dSlo1, respectively) in the absence of auxiliary subunits to explore the mechanism whereby DHA activates Slo1."
24277599
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"In the present study, we found that the profile of BK channel activation by DHA has a bimodal distribution."
29636681
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"We therefore hypothesized that the mechanisms of BK channel activation by DHA are different at low and high concentrations."
29636681
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"Electrophysiological measurements showed that a single residue near the cytoplasmic end of S6 plays a critical role in the DHA activation of human Slo1 as no effect was observed on Drosophila melanogaster Slo1 channels, which normally do not contain DHA in the body."
27965583
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"In addition to direct BK channel activation by DHA, the latter can potentiate BK currents via the cytochrome P450 metabolite 16,17-epoxydocosapentaenoic acid [ xref ]."
29748711
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"To further confirm the relationship between PLC-IP 3 revelated [Ca 2+] i and BK channel activation by DHA, the PLC-IP 3 - [Ca 2+] i signal pathway was blocked, and we found that it attenuated BK activation in CASMCs."
29636681
sparser
"Electrophysiological measurements showed that a single residue near the cytoplasmic end of S6 plays a critical role in the DHA activation of human Slo1 as no effect was observed on Drosophila melanogaster Slo1 channels, which normally do not contain DHA in the body (Hoshi et al., xref )."
27965583
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"In this study, we investigated the mechanisms of BK channel activation by DHA other than that dependent on CYP epoxygenase activity."
29636681
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"In the present study, we found that the profile of BK channel activation by DHA has a bimodal distribution."
29636681
sparser
"We therefore hypothesized that the mechanisms of BK channel activation by DHA are different at low and high concentrations."
29636681
sparser
"An essential fatty acid in humans, DHA is not normally found in the fruit fly Drosophila ; here, xref compared its effects on human and Drosophila Slo1 (hSlo1 and dSlo1, respectively) in the absence of auxiliary subunits to explore the mechanism whereby DHA activates Slo1."
24277599
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"DHA enhanced the BK channel activity in a beta-subunit-dependent manner [XREF_BIBR]."
27834847
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"The counteracting effect of AST and DHA for PA induced BK channel antagonistic activity in the C. elegans model might have restored the normal levels of targeted neurotransmitters."
27834847
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"To further confirm the relationship between PLC–IP 3 revelated [Ca 2+ ] i and BK channel activation by DHA, the PLC–IP 3 –[Ca 2+ ] i signal pathway was blocked, and we found that it attenuated BK activation in CASMCs."
29636681
sparser
"DHA-induced BK channel activation at low concentrations (<1 μM) is mediated through CYP epoxygenase metabolites, while DHA at high concentrations (>1 μM) directly activates BK channels, probably by binding to the S6 segment in the α-subunit."
29636681